DESCRIPTION Orphenadrine 100 mg
Orphenadrine Norflex citrate citrate salt of orphenadrine: (2-dimethyl-2-aminoethyl ether methylbenzhydryl citrate). This occurs as a white crystalline powder with a bitter taste. He has virtually no odor, sparingly soluble in water, slightly soluble in alcohol and has a molecular weight of 461.51.
Orphenadrine citrate, each tablet contains the long-acting 100 mg orphenadrine citrate. Orphenadrine citrate extended-release tablets also contain: calcium stearate, ethylcellulose, and lactose monohydrate.
ACTION Orphenadrine 100 mg
Mode of therapeutic action is not clearly defined, but may be related to its analgesic properties. Orphenadrine citrate has anticholinergic actions.
INDICATIONS Orphenadrine 100 mg
Orphenadrine citrate is indicated as an adjunct to rest, physical therapy and other measures to alleviate the discomfort associated with acute painful musculo skeletal conditions. The mechanism of action of the drug has not been clearly defined, but may be related to its analgesic properties. Orphenadrine citrate does not directly relax tense skeletal muscles in man.
CONTRAINDICATIONS Orphenadrine 100 mg
Contraindicated in patients with glaucoma, pyloric or duodenal obstruction, stenosing peptic ulcer disease, prostatic hypertrophy or obstruction of the bladder neck, cardio-spasm (megaesophagus) and myasthenia gravis.
Contraindicated in patients who have shown prior hypersensitivity to the drug.
WARNINGS Orphenadrine 100 mg
Some patients may experience transient episodes of vertigo, dizziness or fainting. Orphenadrine citrate may impair patients’ ability to engage in potentially hazardous activities such as operating machinery or driving a car, ambulatory patients should be cautioned accordingly.
PREGNANCY Orphenadrine 100 mg
Pregnancy Category C. Safe use of orphenadrine citrate has not been established with respect to adverse effects on fetal development. Thus, orphenadrine citrate should be used in women of childbearing age, especially in early pregnancy only if in the opinion of the doctor, the potential benefits outweigh the possible hazards.
Pediatric use Orphenadrine 100 mg
Safety and effectiveness in children have not been established, so this drug is not recommended for use in the pediatric age group.
Precautionary measures Orphenadrine 100 mg
Confusion, anxiety and tremors have been reported in several patients receiving propoxyphene and orphenadrine together. Since these symptoms may be simply due to an additive effect, reduction of dosage and / or termination of one or both agents is recommended in such cases.
Orphenadrine citrate should be used with caution in patients with tachycardia, cardiac insufficiency, coronary insufficiency, cardiac arrhythmias.
Safety of continuous long-term therapy with orphenadrine has not been established. Therefore, if orphenadrine is prescribed for prolonged use, periodic monitoring of the values of blood, urine and liver function is recommended.
SIDE Orphenadrine 100 mg
Adverse reactions orphenadrine mainly because of the mild anticholinergic action of orphenadrine, and are usually associated with a higher dosage. Dry mouth, usually the first adverse effect to appear. If the daily dose is increased, the possible side effects include tachycardia, palpitation, urinary hesitancy or retention, blurred vision, dilated pupils, increased ocular tension, weakness, nausea, vomiting, headache, dizziness, constipation, drowsiness, allergic reactions, pruritus, hallucinations, agitation, tremor, gastric irritation, and rarely urticaria and other dermatoses. Infrequently, an elderly patient may experience some degree of confusion. These side effects can usually be eliminated by dose reduction. Very rare cases of aplastic anemia associated with the use of orphenadrine tablets have been reported. No causal relationship has not been established.
DOSAGE AND ADMINISTRATION Orphenadrine 100 mg
Adults-Two tablets a day, one in the morning and one in the evening.
